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Antibody System Recombinant Mouse CXCL13/BCA-1/BLC Protein, N-His-SUMO

Antibody System Recombinant Mouse CXCL13/BCA-1/BLC Protein, N-His-SUMO

Product Overview
Accelerate your immunology and lymphoid tissue research with the Antibody System Recombinant Mouse CXCL13/BCA-1/BLC Protein (N-His-SUMO). Chemokine (C-X-C motif) ligand 13 (CXCL13)—also widely recognized as B cell-attracting chemokine 1 (BCA-1) or B lymphocyte chemoattractant (BLC)—is a critical homeostatic chemokine. It is constitutively expressed in secondary lymphoid organs, driving the selective homing, positioning, and orchestration of B cells and follicular helper T (Tfh) cells within lymphoid follicles.
This recombinant protein is expressed in a highly efficient E. coli system and features an N-terminal His-SUMO tag, engineered specifically to enhance soluble protein expression, folding accuracy, and long-term structural stability.
 
DATASHEET

  • PRODUCT INFO

    Key Features & Specifications

    • Optimized Expression Tag: Engineered with an N-terminal His-SUMO tag to maximize solubility, native conformation, and stability during downstream applications.

    • High Purity Standards: Verified at >90% purity using SDS-PAGE analysis, ensuring reliable experimental outcomes with minimal assay background.

    • Advanced Lyophilization Matrix: Stabilized in a protective solution of PBS (pH 7.4), 0.02% NLS, 1mM EDTA, 4% Trehalose, and 1% Mannitol to secure structural integrity.

    • Versatile Workflow Integration: Fully compatible with ELISA, Western Blotting (WB), SDS-PAGE, and immunogen preparation. Bioactivity testing is currently in progress.

    Technical Specifications

    Feature Details
    Catalog No. YMA82501
    Species Mus musculus (Mouse)
    Expression System E. coli
    Accession Number Q3U1E8
    Sequence Range Ile22–Ala109
    Predicted Mol. Weight 23.49 kDa
    Form Lyophilized powder
    Endotoxin Level Available upon request (Contact Lab)

    Alternative Names: CXCL13, BCA-1, BCA1, BLC, SCYB13, B cell-attracting chemokine 1, B lymphocyte chemoattractant, Small-inducible cytokine B13, CXC chemokine BLC, C-X-C motif chemokine 13, Angie.

    Biological Context & Research Applications

    CXCL13 acts as the selective ligand for the CXCR5 chemokine receptor. The CXCL13-CXCR5 axis is paramount for the spatial organization of germinal centers, lymphoid organogenesis, and the development of mucosal immunity. This recombinant mouse protein is an essential tool for evaluating:

    • The molecular architecture of B-cell trafficking and follicle compartmentalization.

    • Chronic inflammatory pathways, ectopic lymphoid tissue formation, and autoimmune pathology.

    • The role of follicular microenvironments in humoral immune responses and antibody production models.

    Handling, Reconstitution & Storage

    • Shipping: Distributed under temperature-controlled conditions on blue ice or dry ice to safeguard protein viability upon arrival.

    • Reconstitution: Reconstitute using sterile water to create a stable primary stock solution.

    • Storage Framework:

      • Short-Term: Store at 2°C to 8°C for up to one week of routine, frequent usage.

      • Long-Term: Store at -20°C (or -80°C) for up to 12 months from the date of receipt.

      • Note: Use a manual defrost freezer and avoid repeated freeze-thaw cycles to keep the protein at peak activity.

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