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Antibody System Recombinant Human GDF11/BMP11 Protein, Tag-Free

Antibody System Recombinant Human GDF11/BMP11 Protein, Tag-Free

Product Overview
Accelerate your cellular development and aging research with the Antibody System Recombinant Human GDF11/BMP11 Protein (Tag-Free). Growth/Differentiation Factor 11 (GDF11)—also known as Bone Morphogenetic Protein 11 (BMP11)—is a highly conserved member of the TGF-beta superfamily. It acts as a major circulating factor regulating embryonic patterning, neurogenesis, muscle homeostasis, and vascular rejuvenation pathways.
This recombinant protein is expressed in mammalian cells to ensure authentic post-translational modifications, proper disulfide-bond formation, and native-like biological activity. Formulated completely tag-free, it eliminates any potential steric hindrance or non-specific interference caused by artificial fusion tags, making it the ideal choice for sensitive functional assays and in vitro cell culture studies.
 
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  • PRODUCT INFO

    Technical Specifications

    Feature Details
    Catalog No. EHB63001
    Species Homo sapiens (Human)
    Expression System Mammalian Cells
    Accession Number O95390
    Sequence Range Asn299–Ser407
    Predicted Mol. Weight 12.5 kDa
    Form Lyophilized powder
    Endotoxin Level Available upon request (Contact Lab)

    Alternative Names: GDF11, GDF-11, BMP11, BMP-11, Growth/differentiation factor 11, Bone morphogenetic protein 11.

    Biological Context & Research Applications

    GDF11 signals through the Activin type II receptors (ActRIIA and ActRIIB) to activate the Smad2/3 pathway. Given its multifaceted physiological impact, this tag-free recombinant protein serves as an indispensable tool for investigating:

    • The molecular mechanisms of systemic aging, tissue rejuvenation, and metabolic regulation.

    • Skeletal muscle development, neuromuscular junctions, and muscle wasting pathologies.

    • Anterior-posterior patterning during embryonic development and mammalian organogenesis.

    Handling, Reconstitution & Storage

    • Shipping: Securely distributed under temperature-controlled conditions on blue ice or dry ice to maximize protein stability.

    • Reconstitution: Reconstitute in sterile water to create a stable primary stock solution.

    • Storage Framework:

      • Short-Term: Store at 2°C to 8°C for up to one week of routine, frequent laboratory use.

      • Long-Term: Store at -20°C (or -80°C) for up to 12 months from the date of receipt.

      • Note: Use a manual defrost freezer and avoid repeated freeze-thaw cycles to prevent loss of protein activity.

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