top of page
Antibody System Recombinant Human IL17F Protein, C-His (Active)

Antibody System Recombinant Human IL17F Protein, C-His (Active)

Product Overview
Accelerate your autoimmune disease and mucosal immunity workflows with the Antibody System Recombinant Human IL17F Protein (C-His, Active). Interleukin-17F (IL-17F) is a homodimeric proinflammatory cytokine predominantly produced by activated Th17 cells. It plays a foundational role in host defense against bacterial and fungal pathogens, cellular chemotaxis, and tissue inflammation by driving the expression of downstream chemokines, cytokines, and antimicrobial peptides at mucosal interfaces.
 
Expressed in mammalian cells to ensure authentic disulfide-linked structural conformation and native post-translational modifications, this recombinant protein is engineered with a C-terminal His-tag for streamlined tracking, purification, and detection. Fully validated for biological activity, it serves as a highly reliable tool for functional screening, therapeutic antibody development, and signaling assay integration.
 
 
DATASHEET

  • PRODUCT INFO

    Key Features & Specifications

    • Biologically Active: Rigorously validated for bioactivity, ensuring optimal ligand-receptor engagement and downstream signaling activation in functional assay setups.

    • Mammalian Cell Expression: Produced in mammalian cells to guarantee native-like folding, correct homodimerization architecture, and high physiological relevance.

    • Premium Purity Standards: Verified at an exceptional >95% purity via SDS-PAGE evaluation, minimizing experimental background noise.

    • Low Endotoxin Footprint: Stringently tested at <1 EU/µg using the LAL assay, making it highly secure for sensitive cell culture experiments.

    • Optimized Storage Matrix: Lyophilized from a 0.22 $\mu$m filtered solution in 20mM PB and 150mM NaCl (pH 7.4) to lock in structural stability.

    Technical Specifications

    Feature Details
    Catalog No. AHJ41201
    Species Homo sapiens (Human)
    Expression System Mammalian Cells
    Accession Number AAH70124.1
    Sequence Range Arg31–Gln163
    Predicted Mol. Weight 15.96 kDa
    Form Lyophilized powder

    Alternative Names: IL17F, IL-17F, Interleukin-17F, Cytokine ML-1.

    Biological Context and Research Applications IL-17F shares receptor subunits (IL-17RA and IL-17RC) with IL-17A, coordinating tissue-specific immune responses through the activation of the NF-kappaB, MAPK, and JAK/STAT pathways. This active, His-tagged human recombinant protein is highly suited for exploring:

    • The molecular mechanisms driving chronic inflammatory diseases, such as psoriasis, rheumatoid arthritis, and inflammatory bowel disease (IBD).

    • Epithelial barrier regulation and neutrophil recruitment mechanisms during acute inflammation or pathogen invasion.

    • The development, screening, and validation of target-specific small molecule inhibitors and neutralizing antibodies.

    Handling, Reconstitution and Storage

    • Shipping: Distributed under temperature-controlled conditions on blue ice or dry ice to ensure maximum protein stability upon arrival.

    • Reconstitution: Reconstitute in sterile water to prepare a primary stock solution. A product-specific technical datasheet will accompany the shipment for detailed guidance.

    • Storage Framework:

      • Short-Term: Store at 2 to 8 degrees Celsius for up to one week of routine, frequent laboratory use.

      • Long-Term: Store at -20 to -80 degrees Celsius for up to 12 months from the date of receipt.

      • Note: Utilize a manual defrost freezer and avoid repeated freeze-thaw cycles to safeguard protein activity.

Heading 6

Related Products

bottom of page