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Antibody System Recombinant Dog IL11 Protein, C-Fc

Antibody System Recombinant Dog IL11 Protein, C-Fc

Product Overview
Advance your veterinary immunology and hematopoiesis research with the Antibody System Recombinant Dog IL11 Protein (C-Fc). Interleukin-11 (IL-11) is a multifunctional cytokine belonging to the IL-6 superfamily. It acts as a major regulator of platelet production (megakaryocytopoiesis) and plays a key role in modulating bone metabolism, protecting mucosal epithelial barriers, and regulating inflammatory responses.
This recombinant protein is expressed in mammalian cells to ensure native-like post-translational modifications and correct folding. Engineered with a C-terminal Fc-tag, this product features an extended half-life and enhanced stability, making it an optimized tool for long-term functional assays and multi-platform screen testing.
 
 
DATASHEET

  • PRODUCT INFO

    Key Features & Specifications

    • Mammalian Expression System: Produced in mammalian cells to guarantee native-like conformation, glycosylation profiles, and physiological relevance.

    • C-Fc Tag Integration: Fused with a C-terminal Fc-tag to optimize protein dimerization, simplify downstream purification, and improve stability during assays.

    • Premium Purity Standards: Verified at >90% purity using SDS-PAGE evaluation, ensuring reliable results with minimal background interference.

    • Advanced Lyophilization Matrix: Stabilized in a balanced mixture of PBS (pH 7.4), 1mM EDTA, 4% Trehalose, and 1% Mannitol to secure structural stability.

    Technical Specifications

    Feature Details
    Catalog No. EQD42201
    Species Canis lupus familiaris (Dog)
    Expression System Mammalian Cells
    Accession Number XP_038511867.1
    Sequence Range Pro22–Leu199
    Predicted Mol. Weight 45.09 kDa
    Form Lyophilized powder
    Endotoxin Level Available upon request (Contact Lab)

    Alternative Names: IL11, IL-11, Interleukin-11, Adipogenesis Inhibitory Factor, AGIF, Oprelvekin.

    Biological Context & Research Applications

    IL-11 interacts with the IL-11Rα receptor chain and the shared gp130 signal transducer to trigger downstream JAK/STAT pathway signaling. In canine research, this pathway is critical for investigating:

    • Megakaryocyte maturation, platelet synthesis, and thrombocytopenia mitigation strategies.

    • Canine osteosarcoma pathways, osteoclastogenesis, and bone remodeling.

    • Gastrointestinal mucosal barrier repair mechanisms and systemic anti-inflammatory signaling.

    Handling, Reconstitution & Storage

    • Shipping: Distributed as a lyophilized powder or frozen liquid on dry ice or blue ice to preserve premium quality upon arrival.

    • Reconstitution: Reconstitute using sterile water to prepare a stable primary stock solution.

    • Storage Framework:

      • Short-Term: Store at 2°C to 8°C for up to one week of routine, frequent usage.

      • Long-Term: Store at -20°C for up to 12 months from the date of receipt.

      • Note: Use a manual defrost freezer and avoid repeated freeze-thaw cycles to keep the protein at peak performance.

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