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Sartorius Biostat® B-DCU Bioreactor

Sartorius Biostat® B-DCU Bioreactor

winselluma is an authorized distributor of the Sartorius Biostat® B-DCU Bioreactor, offering reliable access to this advanced bioprocessing solution. Designed for precise control and scalability, the Biostat B-DCU supports a wide range of cell culture and fermentation applications. By partnering with winselluma, customers benefit from expert support and comprehensive service throughout their purchasing experience. This bioreactor system enhances productivity and ensures consistent results for your biomanufacturing needs. Trust winselluma to connect you with cutting-edge technology that drives innovation.

  • Product Info

    The Biostat® B-DCU is the high-end, industrial-grade evolution of the standard Biostat® B. It is specifically engineered for advanced process development, characterization, and scale-down modeling, offering significantly more control and expansion capabilities than its predecessor.

     

    Advanced Control Architecture

    • Multi-Vessel Independence: A single control tower can manage up to 6 vessels simultaneously and independently, making it ideal for Design of Experiments (DoE) and parallel optimization.

    • Industrial DCU Hardware: Features a 19-inch glove-compatible touchscreen and a high-performance Digital Control Unit (DCU) designed for 24/7 operation and complex automation tasks.

    • Modular Expansion: The system uses individual supply towers for each vessel, allowing for a flexible "plug-and-play" setup where additional units can be added as laboratory requirements grow.

     

    Precision Gassing and Feeding

    • Digital MFCs: Equipped with high-precision digital Mass Flow Controllers (MFCs) featuring a wide 1:200 flow range. This allows the same controller to handle both low-flow mammalian cultures and high-demand microbial fermentations.

    • Sophisticated Cascades: Supports advanced dissolved oxygen (DO) control by simultaneously managing stirring speed, gas flow, and O2 enrichment across multiple vessels.

    • Integrated Pumping: Includes up to four variable-speed peristaltic pumps per vessel for ultra-precise nutrient dosing, pH adjustment, and antifoam control.

     

    Analytical and PAT Integration

    The B-DCU is designed as a hub for Process Analytical Technology (PAT) to reduce manual sampling and increase data density:

    • Metabolic Monitoring: Integrated support for BioPAT® Xgas, providing real-time calculations for Oxygen Uptake Rate (OUR), Carbon Dioxide Evolution Rate (CER), and Respiratory Quotient (RQ).

    • Biomass Control: Compatible with BioPAT® Viamass (viable biomass) and BioPAT® Fundalux (total biomass) for automated monitoring and harvesting.

    • Nutrient Control: Direct integration with BioPAT® Trace for online glucose and lactate monitoring with automated feed-back loops.

     

    Technical Specifications

    • Vessel Compatibility: * Autoclavable Glass (UniVessel®): 1 L, 2 L, 5 L, and 10 L.

      • Single-Use (UniVessel® SU): 2 L.

    • Temperature Range: Precise thermal control from 8°C above coolant temperature up to 80°C.

    • Software Connectivity: Seamlessly integrates with DeltaV™, Biobrain® Supervise, and BioPAT® MFCS for comprehensive data logging and 21 CFR Part 11 compliance.

     

    Primary Applications

    • Scale-Down Modeling: Replicating industrial-scale conditions (up to 2,000 L) at the benchtop for troubleshooting or optimization.

    • High-Cell Density Fermentation: Managing the extreme oxygen and cooling demands of concentrated microbial cultures.

    • Regulatory Characterization: Providing the precise, reproducible data required for Process Characterization (PC) studies and IND/BLA filings.

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