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Sartorius Biostat® RM & Flexsafe® RM

Sartorius Biostat® RM & Flexsafe® RM

Sartorius Biostat® RM and Flexsafe® RM, offering reliable bioreactor systems and single-use bags designed for efficient cell culture and fermentation processes. These solutions provide advanced control and flexibility to optimize bioprocess performance, supporting scalability and reproducibility. With winselluma’s commitment to quality and service, customers gain access to trusted equipment that meets industry standards. Partner with winselluma to enhance your biomanufacturing workflow with Sartorius’ innovative technologies.

  • Product Info

    The Biostat® RM and its corresponding Flexsafe® RM bags form a high-performance wave-mixed bioreactor system. This technology utilizes a rocking motion to provide low-shear aeration and mixing, making it the industry standard for seed train expansion and the cultivation of shear-sensitive cells.

     

    Biostat® RM 

    The Biostat® RM is the rocking platform and control unit designed for flexibility and ease of use in both R&D and cGMP environments.

    • Rocking Motion: Provides effective gas transfer without the use of an impeller. The rocking angle and speed are fully adjustable to optimize oxygen transfer (kLa) while maintaining a low-shear environment.

    • Modular Design: Available as a basic system for simple applications or as an advanced version (Biostat® RM TX) with expanded automation for cell therapy.

    • Control Integration: Managed by the BioPAT® DCU controller, allowing for precise regulation of temperature, pH, DO, and rocking parameters via a user-friendly touchscreen.

    • Scalability: Supports culture volumes from 100 mL up to 100 L (depending on the model), serving as a reliable scale-down model for larger wave systems.

     

    Flexsafe® RM

    Flexsafe® RM bioreactor bags are the single-use "vessels" specifically engineered for the Biostat® RM rocking platform.

    • Advanced Film Technology: Made from Flexsafe® film, which utilizes a highly consistent, S80 polyethylene contact layer. This ensures excellent cell growth by eliminating the risk of toxic leachables and extractables (L&E).

    • Integrated Sensing: Available with pre-installed, single-use optical sensors for pH and DO, allowing for non-invasive monitoring and automated control.

    • Gassing and Porting: Equipped with sterile filters for inlet and exhaust gas, as well as multiple C-Flex® or TuFlux® tubing lines for sterile welding and liquid transfer.

    • Vessel Configurations:

      • Basic: For simple expansion without integrated sensors.

      • Optical: Includes pH and DO sensors for closed-loop control.

      • Perfusion: Features an internal filter membrane for high-density culture applications and continuous processing.

     

    Technical Specifications

    • Rocking Angle: Adjustable from 4° to 12°.

    • Rocking Rate: 2 to 42 rocks per minute (rpm).

    • Temperature Control: Integrated heating plate with a range from ambient +5°C to 50°C.

    • Gas Mixing: Built-in mass flow controllers for Air, O2, N2, and CO2.

     

    Primary Applications

    • Seed Train: Ideal for the expansion of CHO or other mammalian cell lines to inoculate larger stirred-tank bioreactors (N-1 stage).

    • Cell and Gene Therapy: Specifically optimized for the expansion of T-cells, NK cells, and stem cells where gentle mixing is critical for cell viability.

    • Transient Protein Expression: Rapid production of proteins at the 10 L to 100 L scale.

    • Vaccine Production: Cultivation of adherent cells using microcarriers or suspension-adapted virus producers.

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